Structure, dynamics and reactions of protein hydration water
نویسندگان
چکیده
منابع مشابه
Hydration Water Dynamics and Instigation of Protein Structural Relaxation
FOR WEB PUBLICATION The evolution of water dynamics from dilute to very high concentration solutions of a prototypical hydrophobic amino acid with its polar backbone, N-acetyl-leucine-methylamide (NALMA), is studied by quasielastic neutron scattering and molecular dynamics simulation for the completely deuterated leucine monomer. We observe several unexpected features in the dynamics of these b...
متن کاملCoupling of protein and hydration-water dynamics in biological membranes.
The dynamical coupling between proteins and their hydration water is important for the understanding of macromolecular function in a cellular context. In the case of membrane proteins, the environment is heterogeneous, composed of lipids and hydration water, and the dynamical coupling might be more complex than in the case of the extensively studied soluble proteins. Here, we examine the dynami...
متن کاملProtein dynamics: hydration and cavities.
The temperature-pressure behavior of proteins seems to be unique among the biological macromolecules. Thermodynamic as well as kinetic data show the typical elliptical stability diagram. This may be extended by assuming that the unfolded state gives rise to volume and enthalpy-driven liquid-liquid transitions. A molecular interpretation follows from the temperature and the pressure dependence o...
متن کاملDynamical coupling between protein conformational fluctuation and hydration water: Heterogeneous dynamics of biological water
We investigate dynamical coupling between water and amino acid side-chain residues in solvation dynamics by selecting residues often used as natural probes, namely tryptophan, tyrosine and histidine, located at different positions on protein surface and having various degrees of solvent exposure. Such differently placed residues are found to exhibit different timescales of relaxation. The total...
متن کاملInvestigating hydration dependence of dynamics of confined water: monolayer, hydration water and Maxwell-Wagner processes.
The dynamics of water confined in silica matrices MCM-41 C10 and C18, with pore diameter of 21 and 36 A, respectively, is examined by broadband dielectric spectroscopy (10(-2)-10(9) Hz) and differential scanning calorimetry for a wide temperature interval (110-340 K). The dynamics from capillary condensed hydration water and surface monolayer of water are separated in the analysis. Contrary to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
سال: 2004
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2004.1497